期刊
BMB REPORTS
卷 42, 期 5, 页码 265-270出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2009.42.5.265
关键词
Flavonoids; IL-8; Kaempferol; NF-kappa B; ROS
资金
- Ministry of Education, Science and Technology of Korea [F104AC010002-06A0301-00230]
- Ministry of Knowledge Economy of Korea
Due to their multiple biological activities, flavonoids have gained attention as potentially useful therapeutics for a variety of diseases including cancer, cardiovascular diseases, and autoimmune diseases. In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells. In addition, phosphorylation and degradation of I kappa B alpha and translocation of NF-kappa B p65 were inhibited by these flavonoids in TNF-alpha-stimulated HEK 293 cells. Furthermore, generation of reactive oxygen species (ROS) in response to TNF-alpha was reduced by the flavonoids. Moreover, although pretreatment with fisetin, quercetin, or chrysin decreased cell viability, kaempferol did not. Taken together, these findings suggest that kaempferol would be useful for the treatment of TNF-alpha-induced inflammatory diseases. [BMB reports 2009; 42(5): 265-270]
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