期刊
BMB REPORTS
卷 42, 期 11, 页码 697-704出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2009.42.11.697
关键词
Evolutionary approaches; Function prediction; Membrane protein; Protein structure; Topology prediction
资金
- Korea Science and Engineering Foundatio [M10753020006-07N5302-00610, R01-2007-000-20425-0]
- World Class University program [R31-2008-000-10100-0]
- National Research Foundation of Korea [R01-2007-000-20425-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the high-resolution structures; of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods. [BMB reports 2009; 42(11): 697-704]
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