期刊
BMB REPORTS
卷 42, 期 8, 页码 516-522出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2009.42.8.516
关键词
Cell proliferation; Estrogen receptor; PKC; PLC-gamma; SH2D4A
资金
- National Natural Science Foundation of China [30370785]
SH2D4A, comprising a single SH2 domain, is a novel protein of the SH2 signaling protein family. We have previously demonstrated SH2D4A is expressed ubiquitously in various tissues and is located in the cytoplasm. In this study we investigated the function of SH2D4A in human embryonic kidney (HEK) 293 cells using interaction analysis, cell proliferation assays, and kinase activity detection. SH2D4A was found to directly bind to estrogen receptor a (ER alpha), and prevent the recruitment of phospholipase C-gamma (PLC-gamma) to ER alpha. Moreover, we observed its inhibitory effects on estrogen-induced cell proliferation, involving the protein kinase C (PKC) signaling pathway. Together, these findings suggested that SH2D4A inhibited cell proliferation by suppression of the ER alpha/PLC-gamma/PKC signaling pathway. SH2D4A may be useful for the development of a new anticancer drug acting as an ER signaling modulator. [BMB reports 2009; 42(8): 516-522]
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据