期刊
BLOOD REVIEWS
卷 27, 期 2, 页码 63-70出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2012.12.004
关键词
JAK2; Acute lymphoblastic leukemia; JAK inhibitors
类别
Considerable attention has focused on the gain-of-function mutations in the Janus kinase-2 (JAK2) tyrosine kinase that are detectable in most patients with a myeloproliferative neoplasm. Activating mutations that target JAK2, as well as JAK1, or CRLF2 and IL7RA, two cytokine receptors with which the JAKs associate in lymphoid cells, have now been identified in a subset of pediatric patients diagnosed with acute lymphoblastic leukemia (ALL), many of whom have a poor prognosis. This review focuses on the biology of these acquired mutations, and discusses the therapeutic benefits for patients that are likely to arise as a consequence of their discovery. (C) 2012 Elsevier Ltd. All rights reserved.
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