期刊
BLOOD PURIFICATION
卷 32, 期 4, 页码 262-265出版社
KARGER
DOI: 10.1159/000330244
关键词
Hemofiltration; Sepsis; Acute tubular apoptosis; Acute kidney injury; High volume hemofiltration; Mediator removal; Septic acute kidney injury
For a long time, acute kidney injury (AKI) was considered to be a primarily hemodynamic condition characterized by a reduction of renal blood flow, induced by either cardiogenic or distributive (septic) shock. Consequently, all efforts to treat AKI were essentially concentrated on increasing renal flow by enhancing cardiac flow output and perfusion pressure. At the beginning of this decade, Bellomo and co-workers produced new and intriguing data in an animal model of septic AKI that undermined existing concepts. They observed that medullar and cortical renal blood flow were both maintained and even increased in septic shock, underscoring that septic AKI was a totally different physiological phenomenon than nonseptic AKI. Also, apoptosis was found to play a more important role in sepsis and septic shock than pure necrosis. Despite these findings, the role of apoptosis as a main mechanism of organ dysfunction remains topic of debate. Copyright (C) 2011 S. Karger AG, Basel
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