期刊
BLOOD PRESSURE
卷 17, 期 -, 页码 13-21出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08038020802488855
关键词
Amlodipine; angiotensin receptor blockers; calcium-channel blockers; combination therapy; hypertension; valsartan
资金
- Novartis Pharma GmbH, Nuernberg, Germany
Aims. This multicenter, open-label, single-ann trial assessed the efficacy of the combination of amlodipine 10 mg and valsartan 160 mg to provide additional blood pressure reduction and tolerability in patients with moderate hypertension not adequately responding to the combination of ramipril 5 mg and felodipine 5 mg. Results. Of 133 patients treated for 5 weeks with ramipril 5 mg and felodipine 5 mg, 105 failed to achieve mean sitting systolic blood pressure < 140 mmHg. These non-responders were then treated for an additional 5 weeks with amlodipine 10 mg and valsartan 160 mg, which resulted in clinically and statistically significant additional reductions in mean sitting systolic blood pressure of 15.4 mmHg (p < 0.0001) and mean sitting diastolic blood pressure of 7.0 mmHg (p < 0.0001). Adverse event rates were low with both treatment regimens. Conclusions. In hypertensive patients not controlled at 5 weeks by rarnipril 5 mg and felodipine 5 mg) significant additional blood pressure reductions were observed after 5 weeks of treatment with amlodipine 10 mg and valsartan 160 mg. The combination of amlodipine 10 mg and valsartan 160 mg was well tolerated.
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