期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 23, 期 1, 页码 75-77出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0b013e32834d0c81
关键词
Annexin V; bleeding disorder; Scott syndrome
类别
资金
- FAPESP
Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising the platelet procoagulant activity, thrombin generation and, thus, the clot formation. We report a case of a 17-year-old female adolescent with bleeding episodes of unknown cause. She had normal coagulation, but altered platelet aggregation under arteriolar flow, indicating platelet dysfunction. Furthermore, the expression of Annexin V was markedly reduced and the diagnosis of Scott syndrome was established. She was treated with platelet transfusions and demonstrated a clinical improvement. Scott syndrome may be investigated in cases with bleeding history and normal coagulation tests. Blood Coagul Fibrinolysis 23:75-77 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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