期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 22, 期 4, 页码 340-344出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0b013e328344f7e9
关键词
HemosIL HIT-Ab; heparin-induced thrombocytopenia; platelet factor 4/heparin antibody detection
类别
Heparin-induced thrombocytopenia (HIT) is a life-threatening adverse reaction to heparin that must be identified quickly to determine appropriate anticoagulant therapy strategies. The most common antibodies involved in HIT are directed against platelet factor 4/heparin (PF4/H) complexes. Many methods for anti-PF4/H detection exist such as enzyme immunoassays (EIAs), which have been shown to exhibit high-negative predictive value allowing for the exclusion of HIT in the majority of suspected patients; however, most EIAs are performed in a batch mode, thereby delaying results to the physician. HemosIL HIT-Ab((PF4-H)) is a new, rapid method for the detection of total immunoglobulin against PF4/H complexes on ACL TOP Family systems. The assay was evaluated in a multicentre study at three sites with 414 HIT-suspected patients. Using a cut-off value of 1.0 U/ml for HemosIL HIT-Ab((PF4-H)), the new test was compared with Asserachrom HPIA. Results showed a copositivity of 60.2% [95% confidence interval (CI) 48.9-70.8], conegativity of 94.6% (95% CI 91.5-96.7), and overall agreement of 87.7% (95% CI 84.1-90.7). These results are comparable to other PF4/H antibody assays available; with the added benefit of full automation and on-demand testing which provides results at the critical moment when physicians are required to make clinical decisions regarding anticoagulant therapy. Blood Coagul Fibrinolysis 22: 340-344 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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