期刊
GUT MICROBES
卷 6, 期 5, 页码 326-330出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2015.1086057
关键词
colon; commensal bacteria; intestine; ileum; mucus; Muc2; penetrability; proteomics
资金
- Swedish Research Council [7461, 21027, 22220-01-5]
- Swedish Cancer Foundation
- Knut and Alice Wallenberg Foundation
- IngaBritt and Arne Lundberg Foundation
- Sahlgren's University Hospital (LUA-ALF)
- Wilhelm and Martina Lundgren's Foundation
- Assar Gabrielsson's foundation
- Clas Groschinskys foundation
- Torsten och Ragnar Soderbergs Stiftelser
- Sahlgrenska Academy
- National Institute of Allergy and Infectious Diseases [U01AI095473, U01AI095776-03: 9006862]
- NIH
- Swedish Foundation for Strategic Research The Mucus-Bacteria-Colitis Center (MBC) of the Innate Immunity Program
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI095776, U01AI095473] Funding Source: NIH RePORTER
The intestinal mucus is a pivotal part of our intestinal protection. It provides slow diffusion of protective molecules, trapping of luminal material as bacteria and smooth transport in the small intestine. In colon it restricts bacterial access to the epithelium limiting the responses to the enormous bacterial load present at this location. The development of these systems depends on the microbiota composition as seen in our recent study comparing the mucus phenotype in 2 colonies kept in different husbandries within the same SPF animal facility. One colony had impenetrable colonic mucus while the other colony had more penetrable mucus. The mucus phenotypes were transmitted via the microbiota and dear differences in its composition could be detected. Candidates associated with the different colonies were identified but the observed mucus difference could not be assigned to a specific bacterium.
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