期刊
GUT MICROBES
卷 6, 期 6, 页码 392-397出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2015.1107697
关键词
bacterial protein isolation; colonic inflammation; gut microbiota; intestinal immune regulation; surface layer protein A
资金
- NIH [R01 AI093370]
- Department of Defense [CA111002]
- NIH/NCRR Clinical & Translational Science Award
- GatoradeTrust Funds
- Florida Breast Cancer foundation [UL1 RR029890]
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR029890] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI093370] Funding Source: NIH RePORTER
Intestinal immunity is subject to complex and fine-tuned regulation dictated by interactions of the resident microbial community and their gene products with host innate cells. Deterioration of this delicate process may result in devastating autoinflammatory diseases, including inflammatory bowel disease (IBD), which primarily comprises Crohn's disease (CD) and ulcerative colitis (UC). Efficacious interventions to regulate proinflammatory signals, which play critical roles in IBD, require further scientific investigation. We recently demonstrated that rebalancing intestinal immunity via the surface layer protein A (SlpA) from Lactobacillus acidophilus NCFM potentially represents a feasible therapeutic approach to restore intestinal homeostasis. To expand on these findings, we established a new method of purifying bacterial SlpA, a new SlpA-specific monoclonal antibody, and found no SlpA-associated toxicity in mice. Thus, these data may assist in our efforts to determine the immune regulatory efficacy of SlpA in humans.
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