期刊
JOURNAL OF EXTRACELLULAR VESICLES
卷 4, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.3402/jev.v4.27497
关键词
ERC Consortium; DMRR; exRNA; exRNA Atlas; exRNA Portal
类别
资金
- National Institute of General Medical Sciences of the United States National Institutes of Health [GM10331601]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UH3TR000931] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [U54DA036134] Funding Source: NIH RePORTER
The large diversity and volume of extracellular RNA(exRNA) data that will form the basis of the exRNA Atlas generated by the Extracellular RNA Communication Consortium pose a substantial data integration challenge. We here present the strategy that is being implemented by the exRNA Data Management and Resource Repository, which employs metadata, biomedical ontologies and Linked Data technologies, such as Resource Description Framework to integrate a diverse set of exRNA profiles into an exRNA Atlas and enable integrative exRNA analysis. We focus on the following three specific data integration tasks: (a) selection of samples from a virtual biorepository for exRNA profiling and for inclusion in the exRNA Atlas; (b) retrieval of a data slice from the exRNA Atlas for integrative analysis and (c) interpretation of exRNA analysis results in the context of pathways and networks. As exRNA profiling gains wide adoption in the research community, we anticipate that the strategies discussed here will increasingly be required to enable data reuse and to facilitate integrative analysis of exRNA data.
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