期刊
EPILEPSY & BEHAVIOR CASE REPORTS
卷 3, 期 -, 页码 36-38出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ebcr.2015.03.002
关键词
22q11.2 deletion syndrome; Hyperprolinemia; Mental retardation; Epilepsy; Interictal psychosis; Phenytoin-induced hypocalcemia; DiGeorge syndrome
In addition to causing polymalformative syndrome, 22q11.2 deletion can lead to various neuropsychiatric disorders includingmental retardation, psychosis, and epilepsy. However, fewreports regarding epilepsy-related psychosis in 22q11.2 deletion syndrome (22q11.2DS) exist. We describe the clinical characteristics and course of 22q11.2DS in a Japanese patient with comorbid mild mental retardation, childhood-onset localization-related epilepsy, and adult-onset, interictal schizophrenia-like psychosis. From a diagnostic viewpoint, early detection of impaired intellectual functioning and hyperprolinemia in patientswith epilepsy with 22q11.2DS may be helpful in predicting the developmental timing of interictal psychosis. Froma therapeutic viewpoint, special attention needs to be paid to phenytoin-induced hypocalcemia in this syndrome. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据