期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 51, 期 4, 页码 264-270出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.07.005
关键词
Notch; Wnt; HSC; Hematopoiesis; Embryonic hematopoiesis; AGM
类别
资金
- Ministerio Ciencia e Innovacion [PLE2009-0111, SAF2010-15450]
- Red Tematica de Investigacion Cooperativa en Cancer [RD12/0036/0054]
- AGAUR [2009SGR-23, CONES2010-0006]
- AECC
- AIRC
- postdoctoral Marie Curie IEF [PIEF-GA-2011-302226]
- FPI
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels. (C) 2013 Elsevier Inc. All rights reserved.
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