期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 51, 期 4, 页码 271-276出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.07.009
关键词
Zebrafish; Hematopoiesis; Stem cell; Screens; Transplantation
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL048801] Funding Source: Medline
- NIDDK NIH HHS [P50 DK049216] Funding Source: Medline
The zebrafish has become a commonly used model for studying hematopoiesis as a result of its unique attributes. Zebrafish are highly suitable for large-scale genetic and chemical screens compared to other vertebrate systems. It is now possible to analyze hematopoietic lineages in zebrafish and validate cell function via transplantation assays. Here, we review advancements over the past decade in forward genetic screens, chemical screens, fluorescence-activated cell sorting analysis, and transplantation assays. Integrating these approaches enables new chemical and genetic screens that assay cell function within the hematopoietic system. Studies in zebrafish will continue to contribute and expand our knowledge about hematopoiesis, and develop novel treatments for clinical applications. (C) 2013 Elsevier Inc. All rights reserved.
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