期刊
AUTEX RESEARCH JOURNAL
卷 15, 期 1, 页码 54-59出版社
AUTEX
DOI: 10.1515/aut-2015-0016
关键词
Poly-(epsilon-caprolactone); PCL; Chitosan; Electrospinning; Nanofibrous Tubes; Polymer blend
资金
- National Science, Technology and Innovation Plan (NSTIP) strategic technologies program in the Kingdom of Saudi Arabia [09-BIO938-02]
3D tubular scaffolds made from Poly-(epsilon-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS solutions is studied. The influence of different CS solutions (CS/polyethylene glycol (PEO)/glacial acetic acid (AcOH), CS/trifluoroacetic acid (TFA), CS/AcOH) on fibre formation and producibility of nanofibrous tubes is investigated. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) is used to verify the presence of CS in the blended samples. Tensile testing and pore size measurements are done to underline the good prerequisites of the fabricated blended PCL/CS nanofibrous tubes as potential scaffolds for vascular grafts. Tubes fabricated from the combination of PCL and CS dissolved in AcOH possesses properties, which are favourable for future cell culture studies.
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