期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 44, 期 4, 页码 219-223出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2010.02.001
关键词
Gardos channel; Duffy antigen; Sickle cell; Chemokines
类别
资金
- Conseil Regional de la Guadeloupe
- Inserm
- Agence Nationale de la Recherche [R07103H5]
- Conseil Regional de la Guadeloupe
- Inserm
- Agence Nationale de la Recherche [R07103H5]
We investigated the effects of the chemokines IL-8 and RANTES on the activity of the Gardos channel (GC) of sickle red blood cells (SSRBCs). SSRBCs expressing the Duffy antigen receptor for chemokines (DARC) incubated under oxygenated conditions exhibit GC activation. The deoxygenation-stimulated K+ loss via the GC is activated by the chemokines in the Duffy-positive SSRBCs. The percentage of cells with high density is 17 times higher in the Duffy-positive group. These findings are consistent with a greater susceptibility of Duffy-positive SSRBCs to inflammatory chemokines leading to GC activation and cellular dehydration and suggest a coupling, promoted by the sickling process, between DARC and the GC. (c) 2010 Elsevier Inc. All rights reserved.
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