期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 42, 期 3, 页码 279-285出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2009.01.001
关键词
Platelets; Oleuropein; Cycloolivil; Thrombin; Antioxidants; Aggregation
类别
资金
- MEC [BFU2007-60104, CrQ2005-07005]
- Proyecto Hispano-Tunecino [A/8203/ 07]
Oleuropein and (+)-cycloolivil are natural polyphenolic compounds with a significant radical scavenging activity present in olive tree. We have investigated the antiaggregant effects of oleuropein and (+)-cycloolivil isolated from an ethyl acetate extract of olive tree wood. Oleuropein and (+)-cycloolivil reduced the ability of thrombin to stimulate platelet aggregation. Both compounds reduced thrombin-evoked Ca2+ release and entry to a similar extent to hydroxytyrosol. This effect was greater ill platelets from patients with type 2 diabetes mellitus than in controls. Thrombin-, thapsigargin- and 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ)-evoked protein tyrosine phosphorylation, which is involved in Ca2+ signalling and platelet aggregation, is inhibited by oleuropein and (+)-cycloolivil. oleuropein and ( +)-cycloolivil are natural oxygen radical scavengers that reduce thrombin-induced protein tyrosine phosphorylation, Ca2+ signalling and platelet aggregation. These observations suggest that oleuropein and (+)-cycloolivil may prevent thrombotic complications associated to platelet hyperaggregability and be the base for the development of antiaggregant therapeutic strategies. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据