期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 100, 期 8, 页码 3183-3192出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2015-1643
关键词
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资金
- National Institutes of Health [K23HD052550, K24DK062895, P30 AG024827, R01HL112985, UL1 RR024153]
- Children's Hospital of Pittsburgh Research Advisory Committee seed grant
- University of Pittsburgh's National Institutes of Health
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K23HD052550] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000005] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024153] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL112985] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K24DK062895] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG024827] Funding Source: NIH RePORTER
Context: Dosages of vitamin D necessary to prevent or treat vitamin D deficiency in children remain to be clarified. Objective: To determine the effects of vitamin D-3 1000 IU/d on serum 25-hydroxyvitamin D [25(OH)D], PTH, and markers of bone turnover (osteocalcin and collagen type 1 cross-linked C-telopeptide) in black children and white children, and to explore whether there is a threshold level of 25(OH)D associated with maximal suppression of serum PTH concentration. Design: Healthy 8- to 14-year-old Pittsburgh-area black (n = 84) and white (n = 73) children not receiving vitamin supplements, enrolled from October through March from 2008 through 2011, were randomized to vitamin D3 1000 IU or placebo daily for 6 months. Results: The mean baseline concentration of 25(OH) D was <20 ng/mL in both the vitamin D-supplemented group and the placebo group (19.8 +/- 7.6 and 18.8 +/- 6.9 ng/mL, respectively). The mean concentration was higher in the supplemented group than in the placebo group at 2 months (26.4 +/- 8.1 vs 18.9 +/- 8.1 ng/mL; P < .0001) and also at 6 months (26.7 +/- 7.6 vs 22.4 +/- 7.3; P +/- .003), after adjusting for baseline 25(OH)D, race, gender, pubertal status, dietary vitamin D intake, body mass index, and sunlight exposure. Increases were only significant in black children, when examined by race. The association between 25(OH)D and PTH concentrations was inverse and linear, without evidence of a plateau. Overall, vitamin D supplementation had no effect on PTH and bone turnover. Conclusions: Vitamin D3 supplementation with 1000 IU/d in children with mean baseline 25(OH)D concentration <20 ng/mL effectively raised their mean 25(OH)D concentration to >= 20 ng/mL but failed to reach 30 ng/mL. Vitamin D supplementation had no effect on PTH concentrations.
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