期刊
BLOOD
卷 123, 期 13, 页码 2062-2065出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2013-10-535443
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资金
- Canadian Institutes of Health Research [111043]
- Terry Fox Research Institute [1023]
- British Columbia Cancer Foundation
- Michael Smith Foundation for Health Research
- Mildred-Scheel-Cancer-Foundation Fellowship
- UBC
- Canadian Hematology Society
The pathogenesis of primary mediastinal large B-cell lymphoma (PMBCL) is incompletely understood. Recently, specific genotypic and phenotypic features have been linked to tumor cell immune escape mechanisms in PMBCL. We studied 571 B-cell lymphomas with a focus on PMBCL. Using fluorescence in situ hybridization here, we report that the programmed death ligand (PDL) locus (9p24.1) is frequently and specifically rearranged in PMBCL (20%) as compared with diffuse large B-cell lymphoma, follicular lymphoma, and Hodgkin lymphoma. Rearrangement was significantly correlated with overexpression of PDL transcripts. Utilizing high-throughput sequencing techniques, we characterized novel translocations and chimeric fusion transcripts involving PDLs at base-pair resolution. Our data suggest that recurrent genomic rearrangement events underlie an immune privilege phenotype in a subset of B-cell lymphomas.
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