期刊
NEUROBIOLOGY OF STRESS
卷 2, 期 -, 页码 67-72出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2015.07.002
关键词
Post-traumatic stress disorder; Post-mortem; Dendritic spine; FKBP5
资金
- U.S. Army Materiel and Medical Command [W81XWH-11-2-0166]
- Dielmann Family Genetic and Environmental Risk Endowment
- Texas A&M University Online Access to Knowledge (OAK) Fund - University Libraries
- Texas A&M University Online Access to Knowledge (OAK) Fund - Office of the Vice President for Research
- Central Texas Veterans Health Care Systems, Temple
- South Texas Veterans Health Care System, San Antonio, Texas
Genetic variants of the immunophilin FKBP5 have been implicated in susceptibility to post-traumatic stress disorder (PTSD) and other stress-related disorders. We examined the relationship between mushroom, stubby, thin and filopodial spine densities measured with Golgi staining and FKBP5 gene expression in the medial orbitofrontal cortex (BA11) in individuals diagnosed with PTSD and normal controls (n = 8/8). ANCOVA revealed PTSD cases had a significantly elevated density of stubby spines (29%, P < 0.037) and a trend for a reduction in mushroom spine density (25%, p < 0.082). Levels of FKBP5 mRNA were marginally elevated in the PTSD cases (z = 1.94, p = 0.053) and levels correlated inversely with mushroom (Spearman's rho = -0.83, p < 0.001) and overall spine density (rho = -0.75, p < 0.002) and directly with stubby spine density (rho = 0.55, p < 0.027). These data suggest that FKBP5 may participate in a cellular pathway modulating neuronal spine density changes in the brain, and that this pathway may be dysregulated in PTSD. Published by Elsevier Inc.
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