期刊
MILITARY MEDICAL RESEARCH
卷 2, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40779-015-0038-1
关键词
CRISPR-Cas9; Genome editing; Functional genomic screening; Gene therapy; Animal model
资金
- Chinese National Key Program on Basic Research [2012CB945103, 2011CB504202]
- National Natural Science Foundation of China [31430057]
Targeted mutagenesis based on homologous recombination has been a powerful tool for understanding the mechanisms underlying development, normal physiology, and disease. A recent breakthrough in genome engineering technology based on the class of RNA-guided endonucleases, such as clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9, is further revolutionizing biology and medical studies. The simplicity of the CRISPR-Cas9 system has enabled its widespread applications in generating germline animal models, somatic genome engineering, and functional genomic screening and in treating genetic and infectious diseases. This technology will likely be used in all fields of biomedicine, ranging from basic research to human gene therapy.
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