期刊
BLOOD
卷 124, 期 4, 页码 493-502出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-04-512756
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资金
- National Institutes of Health, National Institute of General Medical Sciences [1U54 HL112311-01, 1K01 GM103806-01, 2R01 HL066277-11]
- German Research Foundation [SCHU 2561/1-1]
The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.
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