期刊
BLOOD
卷 123, 期 4, 页码 590-593出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2013-07-517060
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资金
- National Institutes of Health (NIH), Heart, Lung and Blood Institute [R01-HL76409]
- Harvard Catalyst Clinical Research Center
- NIH, National Center for Research Resources [UL1-RR025758]
- NIH, Heart, Lung and Blood Institute [P30-HL101299, K24-HL076446]
Serious adverse cardiovascular events peak in the morning, possibly related to increased thrombosis in critical vessels. Plasminogen activator inhibitor-1 (PAI-1), which inhibits fibrinolysis, is a key circulating prothrombotic factor that rises in the morning in humans. We tested whether this morning peak in PAI-1 is caused by the internal circadian system or by behaviors that typically occur in the morning, such as altered posture and physical activity. Twelve healthy adults underwent a 2-week protocol that enabled the distinction of endogenous circadian effects from behavioral and environmental effects. The results demonstrated a robust circadian rhythm in circulating PAI-1 with a peak corresponding to similar to 6:30 AM. This rhythm in PAI-1 was 8-times larger than changes in PAI-1 induced by standardized behavioral stressors, including head-up tilt and 15-minute cycle exercise. If this large endogenous morning peak in PAI-1 persists in vulnerable individuals, it could help explain the morning peak in adverse cardiovascular events.
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