期刊
ORTHOPEDIC RESEARCH AND REVIEWS
卷 7, 期 -, 页码 1-10出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/ORR.S74068
关键词
autologous chondrocyte implantation; mesenchymal stem cell; knee joint
类别
资金
- Funabashi - Orthopaedic Hospital (Chiba, Japan)
Recently, cell-based therapies have generated great interest in the repair of articular cartilage defects and degeneration. Surgical treatments for these indications have multiple options, including marrow stimulation, osteochondral autograft transplant, and autologous chondrocyte implantation. The autologous chondrocyte implantation technique has been improved using a cell scaffold and other devices. Meanwhile, advanced cell-based therapies, including cultured stem cell treatment, have been studied in clinical trials. Most studies have been designed and authorized by institutional review boards and/or the regulatory agencies of the investigators' countries. For cellular products in regenerative medicine, regulations of many countries are amenable to expedited approval. This paper aims to provide an update on ongoing and prospective cell-based therapies, focusing on articular cartilage injury at designated institutions authorized by the Japanese Pharmaceutical and Medical Device Agency.
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