相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4+T Cell-Mediated Colitis in Mice
Gongxian Liao et al.
GASTROENTEROLOGY (2012)
Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors
Marianna Hoesel et al.
HEPATOLOGY (2012)
Humoral and Cellular Capsid-Specific Immune Responses to Adeno-Associated Virus Type 1 in Randomized Healthy Donors
Philippe Veron et al.
JOURNAL OF IMMUNOLOGY (2012)
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver
Ashley T. Martino et al.
BLOOD (2011)
Immune Responses to AAV in Clinical Trials
Federico Mingozzi et al.
CURRENT GENE THERAPY (2011)
Inflammation Promotes the Loss of Adeno-Associated Virus-Mediated Transgene Expression in Mouse Liver
Ekaterina Breous et al.
GASTROENTEROLOGY (2011)
Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results
Terence R. Flotte et al.
HUMAN GENE THERAPY (2011)
Gene therapy for haemophilia: a long and winding road
K. A. High
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Adeno-associated Virus Vectors Serotype 2 Induce Prolonged Proliferation of Capsid-Specific CD8+T Cells in Mice
Hua Li et al.
MOLECULAR THERAPY (2011)
Capsid-specific T-cell Responses to Natural Infections With Adeno-associated Viruses in Humans Differ From Those of Nonhuman Primates
Hua Li et al.
MOLECULAR THERAPY (2011)
Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer
Brad E. Hoffman et al.
MOLECULAR THERAPY (2011)
Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid Proteins
Amit C. Nathwani et al.
MOLECULAR THERAPY (2011)
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
Federico Mingozzi et al.
NATURE REVIEWS GENETICS (2011)
Adenovirus-Associated Virus Vector-Mediated Gene Transfer in Hemophilia B
Amit C. Nathwani et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines
David M. Markusic et al.
MOLECULAR THERAPY (2010)
Proteasome Inhibitors Decrease AAV2 Capsid-derived Peptide Epitope Presentation on MHC Class I Following Transduction
Jonathan D. Finn et al.
MOLECULAR THERAPY (2010)
Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application
Paul E. Monahan et al.
MOLECULAR THERAPY (2010)
AAV Vectors Avoid Inflammatory Signals Necessary to Render Transduced Hepatocyte Targets for Destructive T Cells
Suryanarayan Somanathan et al.
MOLECULAR THERAPY (2010)
AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
Federico Mingozzi et al.
BLOOD (2009)
Cytotoxic T Lymphocyte Responses to Transgene Product, Not Adeno-Associated Viral Capsid Protein, Limit Transgene Expression in Mice
William M. Siders et al.
HUMAN GENE THERAPY (2009)
Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors
Gary C. Pien et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
Jiangao Zhu et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Cytotoxic-T-Lymphocyte-Mediated Elimination of Target Cells Transduced with Engineered Adeno-Associated Virus Type 2 Vector In Vivo
Chengwen Li et al.
JOURNAL OF VIROLOGY (2009)
Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B
Ou Cao et al.
MOLECULAR THERAPY (2009)
A Preclinical Animal Model to Assess the Effect of Pre-existing Immunity on AAV-mediated Gene Transfer
Hua Li et al.
MOLECULAR THERAPY (2009)
Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo
G. R. Jayandharan et al.
GENE THERAPY (2008)
Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
Li Zhong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
Li Zhong et al.
VIROLOGY (2008)
Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver
Federico Mingozzi et al.
BLOOD (2007)
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer
Ou Cao et al.
BLOOD (2007)
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis
Li Zhong et al.
MOLECULAR THERAPY (2007)
Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo
Chengwen Li et al.
JOURNAL OF VIROLOGY (2007)
CD8+ T-cell responses to adeno-associated virus capsid in humans
Federico Mingozzi et al.
NATURE MEDICINE (2007)
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes
Hua Li et al.
MOLECULAR THERAPY (2007)
Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets
Lili Wang et al.
HUMAN GENE THERAPY (2007)
A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8
Bassel Akache et al.
MOLECULAR THERAPY (2007)
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid
Luk H. Vandenberghe et al.
NATURE MEDICINE (2006)
Loss of Siglec expression on T lymphocytes during human evolution
Dzung H. Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells
E Dobrzynski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response
CS Manno et al.
NATURE MEDICINE (2006)
Identification of mouse AAV capsid-specific CD8+ T cell epitopes
DE Sabatino et al.
MOLECULAR THERAPY (2005)
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors
CE Thomas et al.
JOURNAL OF VIROLOGY (2004)
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
F Mingozzi et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
A flow-cytometry based cytotoxicity assay using stained effector cells in combination with native target cells
M Höppner et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2002)
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
GP Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors
ZY Yan et al.
JOURNAL OF VIROLOGY (2002)
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus
DS Duan et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)