期刊
BLOOD
卷 121, 期 14, 页码 2734-2738出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-06-431122
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类别
资金
- Instituto de Salud Carlos III (ISCIII) [N-2004-FS041085, PI080158, RD06/0020/0004, RD06/0020/0101, EC07/90065]
- Spanish Ministry of Health, Spain
- Pla de Recerca de Catalunya [2009-SGR-168]
- ISCIII [CM08/00027]
Risk associated to FLT3 internal tandem duplication (FLT3-ITD) in patients with acute myeloid leukemia (AML) may depend on mutational burden and its interaction with other mutations. We analyzed the effect of FLT3-ITD/FLT3 wild-type (FLT3wt) ratio depending on NPM1 mutation (NPM1mut) in 303 patients with intermediate-risk cytogenetics AML treated with intensive chemotherapy. Among NPM1mut patients, FLT3wt and low ratio (<0.5) subgroups showed similar overall survival, relapse risk, and leukemia-free survival, whereas high ratio (>= 0.5) patients had a worse outcome. In NPM1wt AML, FLT3-ITD subgroups showed a comparable outcome, with higher risk of relapse and shortened overall survival than FLT3wt patients. Allogeneic stem cell transplantation in CR1 was associated with a reduced relapse risk in all molecular subgroups with the exception of NPM1mut AML with absent or low ratio FLT3-ITD. In conclusion, effect of FLT3 burden is modulated by NPM1 mutation, especially in patients with a low ratio. (Blood. 2013;121(14):2734-2738)
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