期刊
ANALYTICAL CHEMISTRY
卷 87, 期 9, 页码 4617-4620出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac5047246
关键词
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资金
- National Basic Research Program of China [2012CB910601]
- National Nature Science Foundation [21375128, 21190043]
- Creative Research Group Project of the NSFC [21321064]
- National High Technology Research and Development Program of China [2012AA020202]
The specific recognition of biomolecules by artificial antibodies has inspired fascination among chemists and biologists. Herein, we propose a new method to prepare epitope-oriented surface-imprinted nanoparticles with high template utilization efficiency. Using a His-tag as the anchor to facilitate the epitope immobilization/removal and the self-polymerization of dopamine to control the imprinted shell thickness, the prepared epitope-imprinted nanoparticles show specific recognition of the target protein. Moreover, with improved hydrophilicity of the His-tag-anchored epitope, this method opens up a universal route for imprinting epitopes with various polarities.
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