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Saskia Gueller et al.
EXPERIMENTAL HEMATOLOGY (2011)
Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis
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Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
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BLOOD (2010)
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development
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BLOOD (2010)
Adaptor protein Lnk inhibits c-Fms-mediated macrophage function
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LNK Mutations in JAK2 Mutation-Negative Erythrocytosis.
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The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation
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EXPERIMENTAL HEMATOLOGY (2009)
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
Sigal Gery et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes
Chunaram Choudhary et al.
MOLECULAR CELL (2009)
Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
Donald Metcalf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Adaptor protein Lnk associates with Tyr568 in c-Kit
Saskia Gueller et al.
BIOCHEMICAL JOURNAL (2008)
Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model
Li Li et al.
BLOOD (2008)
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells
Winnie F. Tam et al.
BLOOD (2008)
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival
Yoshikane Kikushige et al.
JOURNAL OF IMMUNOLOGY (2008)
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
Sigal Gery et al.
BLOOD (2007)
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Jun Seita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mechanisms of disease: The myeloproliferative disorders
Peter J. Campbell et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Activating FLT3 mutations are detectable in chronic and blast phases of chronic myeloproliferative disorders other than chronic myeloid leukemia
Pei Lin et al.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2006)
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
Jennifer L. Rocnik et al.
BLOOD (2006)
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Natalija Buza-Vidas et al.
GENES & DEVELOPMENT (2006)
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model
BH Lee et al.
ONCOGENE (2005)
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myelold transformation
CH Brandts et al.
CANCER RESEARCH (2005)
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
W Tong et al.
BLOOD (2005)
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and lnk-deficient mice
H Ema et al.
DEVELOPMENTAL CELL (2005)
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
R Ren
NATURE REVIEWS CANCER (2005)
Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
KT Kim et al.
BLOOD (2005)
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)
T Kindler et al.
BLOOD (2005)
Targeted therapies in myeloid leukemia
AM John et al.
SEMINARS IN CANCER BIOLOGY (2004)
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
W Tong et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
The role of FLT3 in haematopoietic malignancies
DL Stirewalt et al.
NATURE REVIEWS CANCER (2003)
Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk
J Lennartsson et al.
EXPERIMENTAL CELL RESEARCH (2003)
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
M Mizuki et al.
BLOOD (2003)
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
L Velazquez et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Enhanced Hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
S Takaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
LM Kelly et al.
BLOOD (2002)
SH2-B and APS are multimeric adapters that augment TrkA signaling
XZ Qian et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
F Hayakawa et al.
ONCOGENE (2000)
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