期刊
BLOOD
卷 119, 期 21, 页码 4949-4952出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-02-414441
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资金
- National Cancer Institute Office of Cancer Genomics [HHSN261200800001E]
- Terry Fox Foundation [019001]
- Genome Canada/Genome British Columbia Grant Competition III
- National Institutes of Health [P50CA130805-01, 1U01CA114778]
- Terry Fox Foundation Strategic Health Research Training Program in Cancer Research at Canadian Institutes of Health Research [TGT-53912]
- Cancer Research Society (Steven E. Drabin Fellowship)
- Michael Smith Foundation for Health Research
Recently, the landscape of single base mutations in diffuse large B-cell lymphoma (DLBCL) was described. Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases. Based on this cohort and a further 157 DLBCL cases analyzed by FISH, the incidence in de novo germinal center B cell-like (GCB) DLBCL is 5% (6 of 115). The fusion appears exclusive to GCB and was not seen in 138 non-GCB cases examined (P = .008, Fisher exact test) but was present at low incidence in follicular lymphoma (1 of 81). In all 7 cases identified, the 3' end of the fusion consists of exons 4 and onwards of TP63. The recurrence, subtype enrichment, and the remarkably conserved nature of the TP63 portion of the fusion suggest an important functional role in the lymphomas that harbor this event. (Blood. 2012;119(21):4949-4952)
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