期刊
BLOOD
卷 119, 期 11, 页码 2469-2473出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-11-389866
关键词
-
类别
资金
- National Natural Science funds [81070403]
- Tianjin Key Natural Science funds [08JCZDJC19200]
- Tianjin Key Technology RD Program [09ZCZDSF03800]
- Key International S&T Cooperation project [2010DFB30270]
- National Science and Technology Major project [2011ZX09302-007-04]
- National Public Health Grand Research Foundation [201202017]
Clinical and laboratory features of 642 consecutive Chinese subjects with primary myelofibrosis (PMF) were analyzed and compared with those of 1054 predominately white subjects with PMF. Chinese subjects were significantly younger, fewer had constitutional symptoms, and fewer had a palpable spleen or liver. Anemia, in contrast, was significantly more common in Chinese as was an increased white blood cell count and low platelet count. The reason for these differences is unclear, but it does not seem to be correlated with delayed diagnosis. A small but significantly increased proportion of Chinese had the JAK2(V617F) mutation but no difference in the frequency of haplotypes associated with PMF in whites. Survival of Chinese with PMF was also significantly longer than that of whites with PMF. We found commonly used staging systems for PMF such as the International Prognostic Scoring System and the Dynamic International Prognostic Scoring System were suboptimal predictors of survival in Chinese with PMF, and we developed a revised prognostic score that should help in comparison of data between studies of PMF in different populations and planning of clinical trials. (Blood. 2012; 119(11):2469-2473)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据