期刊
BLOOD
卷 119, 期 2, 页码 422-433出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-05-353789
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资金
- Medical Research Council
- Wellcome Trust [WT091663MA]
- NIHR (Oxford)
- James Martin School for the 21st Century (Oxford)
- NIAID [NIH NIAID 1U19AI082630-01]
- MRC [G1002552, G108/601, G0800391, G0501638] Funding Source: UKRI
- Medical Research Council [G1002552, G0501638, G0800391, G108/601, G9818340B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10204] Funding Source: researchfish
Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17 CD161(++)CD8 alpha beta(+) T cells exist in cord blood, from which a prominent MAIT cell (TCR V alpha 7.2(+)) population emerges postnatally. During this expansion, CD8 alpha alpha T cells appear exclusively within a CD161(++)CD8(+)/MAIT subset, sharing cytokine production, chemokine-receptor expression, TCR-usage, and transcriptional profiles with their CD161(++)CD8 alpha beta(+) counterparts. Our data demonstrate the origin and differentiation pathway of MAIT-cells from a naive type-17 precommitted CD161(++)CD8(+) T-cell pool and the distinct phenotype and function of CD8 alpha alpha cells in man. (Blood. 2012;119(2):422-433)
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