期刊
BLOOD
卷 118, 期 24, 页码 6258-6268出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-07-356006
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资金
- National Institutes of Health [P01 HL 32262, DK068348, DK067356]
- Singapore-Massachusetts Institute of Technology Alliance [C-382-641-001-091]
- Amgen Inc
- Swedish Research Council
- Diamond-Blackfan Anemia Foundation
- Maja och Hjalmar Leanders Stiftelse
- Sweden-America Foundation
- Croucher Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases [K08 DK076848]
This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)
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