期刊
BLOOD
卷 117, 期 24, 页码 6612-6616出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-06-293266
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资金
- Fondazione Beretta, Brescia, Italy
- Progetto di Eccellenza Fondazione Cassa di Risparmio di Padova e Rovigo
- University of Padova [CPDA074121/07]
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Berlucchi, Brescia, Italy
- Ministero dell'Istruzione
- Ente Cassa di Risparmio di Firenze
- Ministero dell'Istruzione, dell'Universita e della Ricerca [2007H9AWXY, 2008C33HRL_003]
- Fondazione Cariverona
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [5839]
- Borsa di studio Prof Roberto Tosoni (Garda Vita, BCC del Garda)
Lymphoid hyperplasia of gastric mucosa associated with Helicobacter pylori (HP) infection represents a preneoplastic condition of the mucosa associated lymphoid tissue (MALT), which may evolve to a B-cell lymphoma. While it is well established that the initial neoplastic proliferation of B cells is antigen-driven and dependent on the helper activity of HP-specific T cells, it needs to be elucidated which cytokine or soluble factor(s) promote B-cell activation and lymphomagenesis. Herein, we originally report that gastric MALT lymphoma express high levels of a proliferation inducing ligand (APRIL), a novel cytokine crucial in sustaining B-cell proliferation. By immunohistochemistry, we demonstrate that APRIL is produced almost exclusively by gastric lymphomainfiltrating macrophages located in close proximity to neoplastic B cells. We also show that macrophages produce APRIL on direct stimulation with both HP and HP-specific T cells. Collectively, our results represent the first evidence for an involvement of APRIL in gastric MALT lymphoma development in HP-infected patients. (Blood. 2011;117(24):6612-6616)
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