期刊
BLOOD
卷 117, 期 19, 页码 5142-5151出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-01-331306
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资金
- Inserm
- French ANRS
- ANR [ANR-09-JCJC-0114-01]
- Sidaction
- ORVACS
- European Union [LHS-CT-2005-018914]
- Doris Duke Clinical Scientist Development Award
- UCSF Centers for AIDS Research at UCSF [PO AI27763]
- UCSF Clinical and Translational Science Institute [UL1 RR024131]
- NIAID [RO1 AI087145, K24AI069994]
- American Foundation for AIDS Research [106710-40-RGRL]
- Ragon Institute
- [K23 AI065244]
- Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0114] Funding Source: Agence Nationale de la Recherche (ANR)
The mechanisms of CD4(+) T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4(+) T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4(+) T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34(+) hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments. (Blood. 2011; 117(19): 5142-5151)
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