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Sara C. Monroe et al.
EXPERIMENTAL HEMATOLOGY (2011)
The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures
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Early mammalian erythropoiesis requires the Dot1L methyltransferase
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BLOOD (2010)
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BLOOD (2010)
Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes
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CANCER RESEARCH (2010)
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EXPERT OPINION ON THERAPEUTIC TARGETS (2010)
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
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GENES & DEVELOPMENT (2010)
Histone modification levels are predictive for gene expression
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors
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BLOOD (2009)
The molecular biology of mixed lineage leukemia
Robert K. Slany
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)
New insights to the MLL recombinome of acute leukemias
C. Meyer et al.
LEUKEMIA (2009)
ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L
Evan R. Barry et al.
STEM CELLS (2009)
Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
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PLOS BIOLOGY (2009)
The PHD fingers of MLL block MLL fusion protein-mediated transformation
Andrew G. Muntean et al.
BLOOD (2008)
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
Andrei V. Krivtsov et al.
CANCER CELL (2008)
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
David J. Steger et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
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PLOS GENETICS (2008)
Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia
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BLOOD (2008)
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
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BLOOD (2007)
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
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CELL STEM CELL (2007)
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Emmanuelle Bitoun et al.
HUMAN MOLECULAR GENETICS (2007)
Profile of histone lysine methylation across transcribed mammalian chromatin
Christopher R. Vakoc et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
Dimple Bansal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
M Alcalay et al.
BLOOD (2005)
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
MJ Kiel et al.
CELL (2005)
hDOT1L links histone methylation to leukemogenesis
Y Okada et al.
CELL (2005)
A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles
G Testa et al.
GENESIS (2004)
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
T Hisa et al.
EMBO JOURNAL (2004)
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
BB Zeisig et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
PM Ayton et al.
GENES & DEVELOPMENT (2003)
Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase
JR Min et al.
CELL (2003)
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
Q Feng et al.
CURRENT BIOLOGY (2002)
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association
HH Ng et al.
GENES & DEVELOPMENT (2002)
Dot1p modulates silencing in yeast by methylation of the nucleosome core
F van Leeuwen et al.
CELL (2002)
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