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The molecular basis of hepcidin-resistant hereditary hemochromatosis
Augustine Fernandes et al.
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Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
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Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression
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Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization
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Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
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Investigation of the Biophysical and Cell Biological Properties of Ferroportin, a Multipass Integral Membrane Protein Iron Exporter
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Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease
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Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
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Lack of the bone morphogenetic protein BMP6 induces massive iron overload
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
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Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
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Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression
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Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I
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Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
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A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
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Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia
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Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
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Erwin H. J. M. Kemna et al.
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Evidence for the multimeric structure of ferroportin
Ivana De Domenico et al.
BLOOD (2007)
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
Maria Vittoria Verga Falzacappa et al.
BLOOD (2007)
Suppression of hepcidin during anemia requires erythropoietic activity
Mihwa Pak et al.
BLOOD (2006)
Interleukin induces hepcidin expression through STAT3
Diedra M. Wrighting et al.
BLOOD (2006)
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
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NATURE GENETICS (2006)
A role of SMAD4 in iron metabolism through the positive regulation of hepicidin expression
RH Wang et al.
CELL METABOLISM (2005)
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
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BLOOD (2005)
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
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BLOOD (2005)
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
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BLOOD (2005)
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
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JOURNAL OF CLINICAL INVESTIGATION (2005)
A mouse model of juvenile hemochromatosis
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JOURNAL OF CLINICAL INVESTIGATION (2005)
Functional consequences of ferroportin 1 mutations
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BLOOD CELLS MOLECULES AND DISEASES (2005)
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
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CELL METABOLISM (2005)
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
H Kawabata et al.
BLOOD (2005)
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
MD Knutson et al.
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Functional differences between hepcidin 1 and 2 in transgenic mice
DQ Lou et al.
BLOOD (2004)
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
E Nemeth et al.
SCIENCE (2004)
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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
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Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
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BLOOD (2003)
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
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KR Bridle et al.
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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
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