期刊
BLOOD
卷 118, 期 17, 页码 4609-4619出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-12-323972
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资金
- Inserm Avenir program
- Inca
- Association pour la Recherche contre le Cancer (ARC) [4981]
- Feder
- Swiss National Science Foundation [31-112551]
- Fondation pour la Recherche Medicale (FRM)
- Lilly Institute
- Inserm/Region
In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1 alpha BM content in jam-b(-/-) mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment. (Blood. 2011; 118(17): 4609-4619)
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