期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 44, 期 2, 页码 561-572出版社
IOS PRESS
DOI: 10.3233/JAD-140981
关键词
A beta PP transgenic mice; Alzheimer's disease; behavior; exercise; EGCG; learning
资金
- University of Missouri Research Council
- NIH [2P01 AG018357, 1P50 AT006273]
- NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE [P50AT006273] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG018357] Funding Source: NIH RePORTER
Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive functions. Epidemiological studies suggest that exercise and dietary antioxidants are beneficial in reducing AD risk. To date, botanical flavonoids are consistently associated with the prevention of age-related diseases. The present study investigated the effects of 4 months of wheel-running exercise, initiated at 2-months of age, in conjunction with the effects of the green tea catechin (-)-epigallocatechin-3-gallate (EGCG) administered orally in the drinking water (50 mg/kg daily) on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, open-field, anxiety in the light-dark box; and 2) soluble amyloid-beta (A beta) levels in the cortex and hippocampus in TgCRND8 (Tg) mice. Untreated Tg mice showed hyperactivity, relatively poor nest building behaviors, and deficits in spatial learning in the Barnes maze. Both EGCG and voluntary exercise, separately and in combination, were able to attenuate nest building and Barnes maze performance deficits. Additionally, these interventions lowered soluble A beta(1-42) levels in the cortex and hippocampus. These results, together with epidemiological and clinical studies in humans, suggest that dietary polyphenols and exercise may have beneficial effects on brain health and slow the progression of AD.
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