期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 44, 期 2, 页码 375-378出版社
IOS PRESS
DOI: 10.3233/JAD-141890
关键词
Adenosine 5 '-triphosphate (ATP) contents; Alzheimer's disease; Alzheimer's disease transgenic mouse model; oxidative stress
资金
- National Center for Research Resources [P20RR016456]
- Louisiana Board of Regents Support Fund
- NIH [AG032755, AG010483]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016456] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG032755, U19AG010483, U01AG010483] Funding Source: NIH RePORTER
Mitochondrial impairment as evidenced by decline in adenosine 5'-triphosphate (ATP) is associated with oxidative stress in Alzheimer's disease neuropathology and suggests that mitochondria may fail to maintain cellular energy, through reduced ATP production in neurons. To gain insights into the ATP characteristics of Alzheimer's disease transgenic (Tg) mice, we investigated ATP contents in the brain and whole blood of Tg mice at three ages (1-, 5-, and 24-months old). Overall, our results demonstrate that tissue ATP contents in Tg mice are significantly reduced, suggesting a decrease of tissue ATP production and mitochondrial dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据