期刊
BLOOD
卷 117, 期 11, 页码 3104-3112出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-09-307983
关键词
-
类别
资金
- Israel Science Foundation
- Wolens Gerontology Research Fund
- Weisz Gerontology Research Fund
- Atkins Medical Research Fund
Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multi-potent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence. (Blood. 2011; 117(11): 3104-3112)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据