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注意:仅列出部分参考文献,下载原文获取全部文献信息。Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
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Lnk constrains myeloproliferative diseases in mice
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Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
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Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells
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Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells
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Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals
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SOCS2: inhibitor of JAK2V617F-mediated signal transduction
H. Quentmeier et al.
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SOCS regulation of the JAK/STAT signalling pathway
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Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
Ronan Chaligne et al.
BLOOD (2007)
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
Sigal Gery et al.
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The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
Michelle B. Hookham et al.
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Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
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Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis
Francois Delhommeau et al.
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MPL515 mutations in myeloproliferative and other myeloid disorders:: a study of 1182 patients
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BLOOD (2006)
High molecular response rate of polycythemia vera patients treated with pegylated interferon α-2a
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Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
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Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
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MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia
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The molecular mechanisms that control thrombopoiesis
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Identification of an acquired JAK2 mutation in Polycythemia vera
RX Zhao et al.
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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
W Tong et al.
BLOOD (2005)
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and lnk-deficient mice
H Ema et al.
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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
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A gain-of-function mutation of JAK2 in myeloproliferative disorders
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NEW ENGLAND JOURNAL OF MEDICINE (2005)
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
RL Levine et al.
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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
EJ Baxter et al.
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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
W Tong et al.
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Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
L Velazquez et al.
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Enhanced Hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
S Takaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Elevation of serum thrombopoietin precedes thrombocytosis in acute infections
A Ishiguro et al.
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Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-Bβ
LY Rui et al.
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