期刊
BLOOD
卷 117, 期 2, 页码 429-439出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-01-266833
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- National Science Council of Taiwan [NSC 98-3112-B-001-020, NSC 95-2745-B-001-001-MY3, NSC 98-2314-B-002-042-MY3]
- MOEA of Taiwan [98-EC-17-A-01-S1-131]
The C-X-C-type chemokine Cxcl12, also known as stromal cell-derived factor-1, plays a critical role in hematopoiesis during fetal development. However, the functional requirement of Cxcl12 in the adult hematopoietic stem/progenitor cell (HSPC) regulation was still unclear. In this report, we developed a murine Cxcl12 conditional deletion model in which the target gene can be deleted at the adult stage. We found that loss of stroma-secreted Cxcl12 in the adult led to expansion of the HSPC population as well as a reduction in long-term quiescent stem cells. In Cxcl12-deficient bone marrow, HSPCs were absent along the endosteal surface, and blood cell regeneration occurred predominantly in the perisinusoidal space after 5-fluorouracil myelosuppression challenge. Our results indicate that Cxcl12 is required for HSPC homeostasis regulation and is an important factor for osteoblastic niche organization in adult stage bone marrow. (Blood. 2011; 117(2):429-439)
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