期刊
BLOOD
卷 117, 期 1, 页码 242-245出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-06-291658
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资金
- Red Tematica de Investigacion Cooperativa en Cancer [R06/0020/0031]
- Ministerio de Ciencia e Innovacion [BES2008-008053]
- Instituto de Salud Carlos III [CA08/00141, CM09/00038, PI06/0657, 09/01828]
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia. (Blood. 2011;117(1):242-245)
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