期刊
BLOOD
卷 116, 期 7, 页码 1056-1059出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-01-262394
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资金
- National Cancer Institute, National Institutes of Health
- National Cancer Institute providing basic support for the Southern Community Cohort Study [R01 CA092447]
- Susan G. Komen for the Cure [OP05-0927-DR1]
- National Cancer Institute [CA 62242, CA 107-476-03]
- Vanderbilt-Ingram Cancer Center [P30 CA68485]
Obesity and black race have been associated with excess risk of multiple myeloma. The association of obesity with monoclonal gammopathy of undetermined significance (MGUS) is unknown. Further, it is not known whether the increased risk of multiple myeloma and MGUS in blacks is related to socioeconomic status, genetic susceptibility, or both. We screened 1000 black and 996 white women (range, 40-79 years) of similar socioeconomic status for MGUS; the aim of the study was to assess MGUS risk in relation to obesity and race. A total of 39 (3.9%) blacks and 21 (2.1%) whites had MGUS. On multivariate analysis, obesity (odds ratio [ OR] = 1.8; P = .04), black race (OR = 1.8; P = .04), and increasing age (> 55 vs < 43 years; OR = 2.5; P = .03) were independently associated with an excess risk of MGUS. Our findings support the hypothesis that obesity is etiologically linked to myelomagenesis. The 2-fold excess of MGUS among blacks compared with whites of similar socioeconomic status supports a role for susceptibility genes in MGUS. (Blood. 2010;116(7):1056-1059)
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