期刊
BLOOD
卷 113, 期 8, 页码 1829-1833出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-05-155283
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资金
- Ministry of Education, Culture, Sports, Science and Technology (Tokyo, Japan) [20659153]
- Health and Labor Science Research grants (Tokyo, Japan)
- Mitsubishi Pharma Research Foundation (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [20659153] Funding Source: KAKEN
Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NIMAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4(+)CD25(+) regulatory T cell dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation. (Blood. 2009;113:1829-1833)
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