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Thomas Fehr et al.
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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
Manish J. Butte et al.
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Blockade of CTLA-4 on CD4+ CD25+ regulatory T cells abrogates their function in vivo
Simon Read et al.
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Reversal of the TCR stop signal by CTLA-4
Helga Schneider et al.
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Y. Fudaba et al.
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CTLA-4 engagement and regulatory CD4+ CD25+ T cells independently control CD8+-mediated responses under costimulation blockade
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Role of natural killer cell subsets in cardiac allograft rejection
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Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice
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Regulated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
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Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation
T Fehr et al.
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Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
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JOURNAL OF IMMUNOLOGY (2005)
The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade
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Mechanism of action of donor-specific transfusion in inducing tolerance: Role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation
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B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8-T cells in the thymus
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Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
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CD28 ligation induces transplantation tolerance by IFN-γ-dependent depletion of T cells that recognize alloantigens
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B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via R-T interactions
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Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells
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Tolerance in mixed chimerism - a role for regulatory cells?
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Cutting edge:: CD28 controls peripheral homeostasis of CD4+CD25+
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Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation
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BLOOD (2003)
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CURRENT OPINION IN IMMUNOLOGY (2002)
Cutting edge:: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice
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CTLA-4: new insights into its biological function and use in tumor immunotherapy
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Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β
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Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
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Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression
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AMERICAN JOURNAL OF TRANSPLANTATION (2001)
CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway
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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8(+) T cells and prolonged craft survival in a CTLA4-dependent manner
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