期刊
BLOOD
卷 113, 期 23, 页码 5938-5941出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-09-179168
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资金
- Leukemia and Lymphoma Foundation [6021]
- University Cancer Research Fund (Chapel Hill, NC)
- AIDS Malignancies Clinical Trials Consortium [CA121947]
- National Institutes of Health [CA109232, DE018304, CA096500, CA121935, HL083469, T32 AI00741]
The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with KS-associated herpesvirus infection. We identified 15 virally regulated miRNAs in latently infected, nontumorigenic endothelial cells. MiR-143/145 were elevated only in KS tumors, not virally infected endothelial cells. Thus, they represent tumor-specific, rather than virus-specific, miRNAs. Because many tumor suppressor proteins are wild-type in KS and PEL, down-regulation of multiple tumor suppressor miRNAs provides a novel, alternative mechanism of transformation. (Blood. 2009; 113: 5938-5941)
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