期刊
BLOOD
卷 114, 期 19, 页码 4002-4008出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-07-143545
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类别
资金
- National Institutes of Health [PO1 CA94237, P50CA126752]
- Leukemia & Lymphoma Society
Epstein-Barr virus (EBV)-associated B-cell lymphoproliferation is a life-threatening complication after hematopoietic stem cell or solid organ transplantation resulting from outgrowth of EBV-infected B cells that would normally be controlled by EBV-cytotoxic T cells. During the past decade, early detection strategies, such as serial measurement of EBV-DNA load in peripheral blood samples, have helped to identify high-risk patients and to diagnose early lymphoproliferation. Treatment options include manipulation of the balance between outgrowing EBV-infected B cells and the EBV cytotoxic T lymphocyte response and targeting the B cells with monoclonal antibodies or chemotherapy. Major challenges remain for defining indications for preemptive therapies and integrating novel and conventional therapies. (Blood. 2009; 114: 4002-4008)
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