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PTEN is destabilized by phosphorylation on Thr366
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Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NFκB-dependent pathway
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Ubiquitination regulates PTEN nuclear import and tumor suppression
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Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
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Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN
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The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
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Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners
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Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor κB induced by UV radiation
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CANCER CELL (2002)
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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
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The tyrosine kinase inhibitor STI571, like interferon-α, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia
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Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder
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