期刊
BLOOD
卷 114, 期 10, 页码 2168-2171出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-01-197186
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资金
- European LeukemiaNet
- Associazione Italiana contro le Leucemie
- Associazione Italiana per la Ricerca sul Cancro
- Programmi di Ricerca di Rilevante Interesse Nazionale projects
- Fondazione del Monte di Bologna e Ravenna
Dasatinib and nilotinib are tyrosine kinase inhibitors (TKIs) developed to overcome imatinib resistance in Philadelphia-positive leukemias. To assess how Bcr-Abl kinase domain mutation status evolves during sequential therapy with these TKIs and which mutations may further develop and impair their efficacy, we monitored the mutation status of 95 imatinib-resistant patients before and during treatment with dasatinib and/or nilotinib as second or third TKI. We found that 83% of cases of relapse after an initial response are associated with emergence of newly acquired mutations. However, the spectra of mutants conferring resistance to dasatinib or nilotinib are small and nonoverlapping, except for T315I. Patients already harboring mutations had higher likelihood of relapse associated with development of further mutations compared with patients who did not harbor mutations (23 of 51 vs 8 of 44, respectively, for patients who relapsed on second TKI; 13 of 20 vs 1 of 6, respectively, for patients who relapsed on third TKI). (Blood. 2009; 114: 2168-2171)
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